The use of the laryngeal tube versus the endotracheal tube in out-of hospital cardiac arrest and their effects on arterial blood gas analysis

The use of the laryngeal tube versus the endotracheal tube in out-of hospital cardiac arrest and their effects on arterial blood gas analysis: a randomized, controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN54937993

Enrollment

1400

Registered

2014-09-09

Start date

2015-01-01

Completion date

Unknown

Last updated

2016-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiopulmonary resuscitation, airway management Circulatory System Cardiac arrest

Interventions

Patients will receive either: 1. Intubation with laryngeal tube 2. Intubation with endotracheal tube after cardiac arrest.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adult patients with an age of >18 years 2. Patients with witnessed OHCA of presumed cardiac origin (determined by the emergency physician) 3. Cardiac arrest patients with ongoing chest compression cardiopulmonary resuscitation

Exclusion criteria

Exclusion criteria: 1. Standardized Lund University Cardiac Arrest System (LUCAS, Physiocontrol, 22370 Lund Sweden) mechanical chest compressions not applied before randomization 2. Traumatic OHCA: 2.1. Cardiac arrest due to exsanguination, strangulation, hanging or drowning 2.2. Cardiac arrest due to presumed intracranial hemorrhage 2.3. Cardiac arrest due to respiratory failure 2.4. Patients with an Allow-natural-death- (AND) or Do-not-attempt-resuscitation (DNAR) order or patients with a terminal illness 2.5 Known or clinically apparent pregnancy 2.6. Airway device has been introduced before the emergency physician has arrived at the scene 2.7 Already established tracheostomy e.g. coniotomy 2.8. Upper airway obstruction due to a foreign body or massive pharyngeal swelling e.g. edema for example due to an allergic reaction 2.9. Ward of the state / prisoner

Design outcomes

Primary

Measure	Time frame
Primary outcome is defined as arterial pCO2 measured within 10 minutes of establishing the secure airway	—

Secondary

Measure	Time frame
1. Any ROSC (only brief signs of circulation of less than 20 minutes, making chest compressions unnecessary) 2. Sustained ROSC (signs of circulation persist for more than 20 minutes, making chest compressions unnecessary) 3. EtCO2 continuously measured by the Lifepak 12/15 Monitor (mean value of all measurements until hospital admission, and mean value in the first 10 minutes after inclusion) 4. Quality of CPR: hands-off times 5. Time needed for airway management 6. Intubation attempts 7. Arterial blood gas analysis within 10 minutes (except apCO2, because primary outcome parameter) and on admission (pH, paCO2, pO2, lactate, BE) 8. EtCO2 on arrival 9. ?etCO2 compared between first measured value and etCO2 on admission 10. changes values of blood gas analysis measurements (?pH, ?pCO2, ?pO2, ?lactate, ?BE) between first measurement on-scene and first measurement at hospital admission 11. Rates of Aspiration revealed by Chest-X-ray after admission 12. 30-days survival 13. 6- months survival 14. Neurological outcome after 6 months, favorable outcome defined as CPC 1 or 2, non-favorable outcome defined as CPS >2 or deceased within 6 months.	—

Measure

Time frame

1. Any ROSC (only brief signs of circulation of less than 20 minutes, making chest compressions unnecessary) 2. Sustained ROSC (signs of circulation persist for more than 20 minutes, making chest compressions unnecessary) 3. EtCO2 continuously measured by the Lifepak 12/15 Monitor (mean value of all measurements until hospital admission, and mean value in the first 10 minutes after inclusion) 4. Quality of CPR: hands-off times 5. Time needed for airway management 6. Intubation attempts 7. Arterial blood gas analysis within 10 minutes (except apCO2, because primary outcome parameter) and on admission (pH, paCO2, pO2, lactate, BE) 8. EtCO2 on arrival 9. ?etCO2 compared between first measured value and etCO2 on admission 10. changes values of blood gas analysis measurements (?pH, ?pCO2, ?pO2, ?lactate, ?BE) between first measurement on-scene and first measurement at hospital admission 11. Rates of Aspiration revealed by Chest-X-ray after admission 12. 30-days survival 13. 6- months survival 14. Neurological outcome after 6 months, favorable outcome defined as CPC 1 or 2, non-favorable outcome defined as CPS >2 or deceased within 6 months.

—

Countries

Austria

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026