Neurology - multiple sclerosis and cognition Nervous System Diseases Multiple sclerosis
Conditions
Interventions
Patients who have a previous diagnosis of multiple sclerosis and who are already attending a neurologist will be screened for eligibility during routine outpatient follow up appointments. Those report
Sponsors
Brighton and Sussex University Hospitals NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosis of MS by consultant neurologist to best current criteria 2. Able and willing to give informed consent 3. Cognitive impairment defined by scoring below 5th percentile on one or more of Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) scales as identified at the clinic 4. Willing to commit to three 45-minute computer training sessions for six weeks 5. Home PC fulfilling experimental spec 6. Willing to attend total of 3 MRI scans at the University of Sussex MRI scanner 7. Age between 18 and 70
Exclusion criteria
Exclusion criteria: 1. Significant change in medications in last 4 weeks 2. Relapse recovery within last 4 weeks 3. Sensorimotor dysfunction likely to interfere with PC interface 4. Significant psychiatric history/condition 5. Significant medical condition (other than MS), personal or social circumstances likely to influence cognition or study participation 6. Women who are pregnant
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| MRI: The data will be acquired on the 1.5T Siemens machine. The following analyses will be completed: 1. Voxel-based morphometry 2. Tensor-based morphometry 3. Cortical thickness 4. Lesion load 5. Resting state analysis (DMN) 6. DTI analysis | — |
Primary
| Measure | Time frame |
|---|---|
| 1. Objective cognitive performance: BICAMS (Brief International Cognitive Assessment for MS), a 15-minute careening tool 2. Quality of life: 2.1. EQ-5D, a generic health-related quality of life scale 2.2. FAMS (Functional Assessment of MS), an MS-specific quality of life scale | — |
Countries
United Kingdom
Outcome results
None listed