The impact of introducing real-time feedback on ventilation rate and volume by ambulance clinicians in out-of-hospital cardiac arrest

The impact of introducing real-time feedback on ventilation rate and volume by ambulance clinicians in out-of-hospital cardiac arrest: the VANZ2 study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN54864230

Enrollment

Registered

2022-08-18

Start date

2021-08-01

Completion date

Unknown

Last updated

2022-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Out-of-hospital cardiac arrest Circulatory System Cardiac arrest

Interventions

This study is a stepped wedge, cluster randomised trial (Hemming et al, 2015), involving three ambulance stations: Blucher, Redcar and Middlesbrough. This design has been chosen so patients are not di

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. All persons aged 18 years and over 2. Eligible for resuscitation in accordance with current European Resuscitation Council guidelines 3. Absence of do not attempt resuscitation (DNAR) order 4. Catchment area for South Tees Hospitals, University Hospital of North Tees, Newcastle Hospitals or Northumbria Specialist Emergency Care Hospital 5. Study paramedics first on scene

Exclusion criteria

Exclusion criteria: 1. Known or apparent pregnancy 2. Traumatic OHCA

Design outcomes

Primary

Measure	Time frame
Compliance with ERC guidelines for ventilation, comprising tidal volume (Vt) delivered with each rescue breath and ventilation rate per minute. ERC guidelines recommend ventilating patients with 8-12 ventilations per minute and a tidal volume (Vt) of 500-600 ml. These data are collected during the out-of-hospital resuscitation period.	—

Secondary

Measure	Time frame
1. Effect on other aspects of care during resuscitation (such as compliance with chest compression guidelines (ERC guidelines regarding rate and depth), evidence of delay in time to defibrillation, time to receive first drug etc). These data are collected during the out-of-hospital resuscitation period. 2. Patient outcomes: 2.1. Return of spontaneous circulation (ROSC) at any time 2.2. Survival to the emergency department (ED) 2.3. Short-term survival (survival to 24 hours) 2.4. Long-term survival (survival to 30 days) 2.5. Neurological function measured using mRS (modified Rankin scale) at 30 days	—

Measure

Time frame

1. Effect on other aspects of care during resuscitation (such as compliance with chest compression guidelines (ERC guidelines regarding rate and depth), evidence of delay in time to defibrillation, time to receive first drug etc). These data are collected during the out-of-hospital resuscitation period. 2. Patient outcomes: 2.1. Return of spontaneous circulation (ROSC) at any time 2.2. Survival to the emergency department (ED) 2.3. Short-term survival (survival to 24 hours) 2.4. Long-term survival (survival to 30 days) 2.5. Neurological function measured using mRS (modified Rankin scale) at 30 days

—

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026