Ear, Nose and Throat Ear, Nose and Throat
Conditions
Interventions
A steady flow of normal air (100 ml/min) is fed into one nostril
the other nostril is left unblocked so air can escape. Simultaneously, the subject breathes via the mouth into an oxygen mouthpiece so that the soft palate closes the mouth from the nasal cavity, and
Sponsors
Record Provided by the NHSTCT Register - 2006 Update - Department of Health
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy adult volunteers between 18 and 40 years old. Volunteers will be recruited from amongst medical and nursing staff and students at St George?s Hospital, London. They will be personally approached by the principle investigator.
Exclusion criteria
Exclusion criteria: 1. Smokers 2. Subjects with a history of chronic respiratory or nasal disease 3. Symptomatic upper respiratory tract infection during the previous 4 weeks 4. Subjects who have taken systemic or topical steroids or anti-histamine therapy during the previous 4 weeks 5. Presence of significant mechanical intra-nasal deformity such as a septal deviation or bony spur 6. Children under 16 years old 7. Vulnerable groups including those with learning difficulty, mental illness and dementia 8. Pregnancy 9. Other conditions that increase risk are hyperthyroidism, obesity, bronchitis, asthma, pre-existing heart disease and alcoholism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The mucociliary clearance time, measured as the time to taste the saccharin | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures | — |
Countries
United Kingdom
Outcome results
None listed