Invasive pneumococcal disease in HIV-infected Africans Infections and Infestations Invasive pneumococcal disease
Conditions
Interventions
Participants are recruited from individuals who are convalescing from a known invasive pneumococcal disease event. They are randomised into two arms in a 1:1 ratio to receive two doses of vaccine one
Sponsors
University of Liverpool (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Confirmed case of IPD discharged from hospital 2. Resident of Blantyre and its immediately neighbouring districts 3. Willing to attend Queen Elizabeth Central Hospital (QECH) when sick 4. Aged over 15 years, either sex 5. Willing to have HIV testing performed on stored serum
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Previous pneumococcal vaccine 3. Active acute systemic illness - following recovery participant may be recruited 4. Past hypersensitivity reaction to vaccination 5. Bed-ridden or life expectancy judged to be less than three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vaccine serotype invasive pneumococcal disease | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. All invasive pneumococcal disease death 2. All cause pneumonia | — |
Countries
Malawi
Outcome results
None listed