Prostate cancer Cancer Malignant neoplasm of the prostate
Conditions
Interventions
Men allocated to the screening arm are invited every second year for PSA testing, until they reach the upper age limit (70 years). Only men with PSA at or above the threshold (greater than or equal to
the incidence of prostate cancer, stage, grade and primary treatment as well as cause of death will be registered in the control group.
Last invitaion to the study will be in 2014 but follow-up will
Sponsors
Sahlgrenska University Hospital (Sweden)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Men born during 1930 through 1944 living in the city of Göteborg, Sweden
Exclusion criteria
Exclusion criteria: 1. Men with a prior diagnosis of prostate cancer 2. Men who had died or emigrated but had not been removed from the Population Register at time of randomisation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prostate cancer specific mortality (absolute and relative risk reduction in cumulative prostate cancer mortality) analysed according to the intention-to-screen principle (comparing the screening group with the control group). Analysed at study completion (after 15 years). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Cumulative prostate cancer incidence and the proportion of screening attendees 2. Comparisons of stage and age distribution 3. Lead and length time bias 4. Quality of life between screened men and controls Analysed at study completion. | — |
Countries
Sweden
Outcome results
None listed