Asthma and obesity Respiratory Asthma and obesity
Conditions
Interventions
Dietary intervention: Meal replacement therapy for six months plus dietition advice and support for intervention group versus healthy eating leaflet for control group
Exhaled nitric oxide measurement
Sponsors
University of Liverpool (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Obesity (body mass index more than 30 kg/m^2 2. Age 18 to 65 years 3. Asthma requiring treatment with at least a long-acting inhaled corticosteroid and an inhaled beta agonist
Exclusion criteria
Exclusion criteria: 1. Subjects on long-term oral corticosteroids 2. Diabetes mellitus 3. Pregnancy or breastfeeding 4. History of major eating disorder 5. History of food allergy to any component of Slimfast 6. Major psychiatric disease 7. Current smokers 8. Uncontrolled thyroid disease 9. History of severe cardiac, hepatic or renal disease, malignancy, or any other condition that might, in the opinion of the investigators preclude completion of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected weight loss in the intensive group of 10 to 12 kg (10 - 20% body weight), compared to minimal weight loss in the conventional group. This should result in significant improvements in pulmonary function i.e. reduced bronchoconstriction, reduced peak flow variability and reduced bronchial hyper-reactivity. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Reduction in systemic inflammation in the intensively treated group 2. Reduction in markers of local airway inflammation in the intensively treated group 3. Improvement in health status of intensively treated group | — |
Countries
United Kingdom
Outcome results
None listed