Atopic disease, asthma Respiratory Asthma
Conditions
Interventions
Sponsors
University Medical Centre Utrecht (UMCU) (Netherlands)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: High-risk newborns. High-risk was defined as either a mother or a father plus a sibling with present or past atopic disease.
Exclusion criteria
Exclusion criteria: 1. Maternal infection in the last week of pregnancy 2. The use of immunomodulatory drugs or antibiotics during pregnancy (mother) 3. The use of antibiotics prenatally (mother and newborn) 4. Prematurity 5. Signs of intra-uterine infection 6. Premature rupture of membranes 7. Presence of congenital disorders of the airways 8. Sever other congenital disorders 9. Need for mechanical ventilation 10. Prolonged administration of extra oxygen 11. Need for intensive care treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and severity of atopic disease at the age of 4 years. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. SCORing Atopic Dermatitis (SCORAD) 2. Lung function 3. Cytokine production 4. Natural Resistance Associated Macrophage Protein (NRAMP) polymorphisms | — |
Countries
Netherlands
Outcome results
None listed