Substitution of calcineurin inhibitors with sirolimus on left ventricular hypertrophy (LVH) of renal transplant recipients (RTR)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN54216890

Enrollment

Registered

2008-05-12

Start date

2004-06-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic allograft nephropathy in renal transplant recipients

Interventions

28 men and 14 women (total of 42 patients) were enrolled in this study. All patients started CNI therapy. Subjects with chronic allograft nephropathy were switched to sirolimus, whereas patients not

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age 25-66 years, both males and females 2. Non diabetic RTR with biopsy-proven chronic allograft nephropathy 3. Patients who have received a single kidney in 2004

Exclusion criteria

Exclusion criteria: 1. Diabetic RTR 2. Patients receiving kidney transplant from living donors 3. Patients receiving dual kidney allograft

Design outcomes

Primary

Measure	Time frame
Changes in left ventricular mass (LVMi) at 12 months	—

Secondary

Measure	Time frame
Changes in serum creatinine as a measure of graft function at 12 months	—

Countries

Italy

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026