Randomised controlled trial of surveillance and no surveillance for patients with Barrett's oesophagus

Randomised controlled trial of surveillance and no surveillance for patients with Barrett's oesophagus: BOSS (Barrett's Oesophagus Surveillance Study)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN54190466

Enrollment

2500

Registered

2008-01-08

Start date

2009-09-01

Completion date

Unknown

Last updated

2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Barrett's oesophagus Digestive System Barrett's oesophagus

Interventions

Upper gastrointestinalendoscopy every 2 years for 10 years

Eligibility

Sex/Gender

All

Age

18 Years to 110 Years

Inclusion criteria

Inclusion criteria: Patients over 18 with endoscopic and histologically proven barrett's oesophagus greater than 1 cm

Exclusion criteria

Exclusion criteria: 1. Unable to give consent 2. Unable to tolerate upper gastrointestinal endoscopy

Design outcomes

Primary

Measure	Time frame
1. All causes mortality 2. Death from adenocarcinoma 3. Development of treatable adenocarcinoma Duration of follow-up: 10 years	—

Secondary

Measure	Time frame
1. Quality of life: Reflux Questionnaire and EQ50 Quality of Life Questionnaire at yearly intervals by post 2. Cost effectiveness of endoscopy	—

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jul 23, 2026