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A Pilot Study of Continuous Negative Pressure (CNEP) In Bronchiolitis

A Pilot Study of Continuous Negative Pressure (CNEP) In Bronchiolitis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN53796751
Enrollment
42
Registered
2004-03-05
Start date
2004-01-01
Completion date
Unknown
Last updated
2021-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchiolitis Respiratory Bronchiolitis

Interventions

Infants were randomised to either standard treatment, or standard with CNEP. Inspired oxygen requirement was measured with a calibrated oxygen analyser placed close to the infant's nos

Sponsors

University Hospital of North Staffordshire (UK)
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Forty two infants admitted with bronchiolitis, who needed more than 40% oxygen therapy to maintain normal levels of arterial oxygen saturation. This was a pilot study. Forty two patients were enrolled between January 1991 and April 1992 in two paediatric hospitals in England (North Staffordshire Hospital and Royal Berkshire Hospital) if they fulfilled the following criteria: 1. Clinical diagnosis of bronchiolitis (irrespective of whether respiratory syncitial virus was isolated) 2. Age 1 year 3. Presence of respiratory failure with fractional inspired oxygen (FiO2) 0.4 to achieve an arterial oxygen saturation (SaO2) of 96-99%.

Exclusion criteria

Exclusion criteria: Infants with bronchopulmonary dysplasia (BPD), congenital cardiac, pulmonary or neuromuscular diseases or signs of upper airway obstruction were excluded.

Design outcomes

Primary

MeasureTime frame
Not provided at time of registration

Secondary

MeasureTime frame
Not provided at time of registration

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026