Fever in Subsaharan Africa

Clinical pattern, severity, management and outcome of acute febrile illness in sub-Saharan Africa

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN53741386

Enrollment

10000

Registered

2019-10-14

Start date

2019-11-25

Completion date

Unknown

Last updated

2026-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Febrile illnesses Signs and Symptoms Fever, unspecified

Interventions

After giving informed consent to participate in the study, each participant will be included and followed for 21 days. Contacts are planned for days 7, 14 and 21 after inclusion. These contacts will b

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Ongoing objectively determined fever, as defined by axillary Temperature >37.5°C, or tympanic (or oral or rectal) temperature >38°C. 2. Contactable by the study team at days 7, 14 and 21. 3. Informed consent to participate signed by the patient (adults) or a legally acceptable representative (children or patients with impaired consciousness) with assent from the concerned, where applicable and possible

Exclusion criteria

Exclusion criteria: 1. Children under 2 months 2. Hospitalization in the last 14 days

Design outcomes

Primary

Measure	Time frame
Clinical status is measured using a three-category ordinal scale (resolved, not resolved, dead) at day 7.	—

Secondary

Measure	Time frame
1. Clinical status is measured using a three-category ordinal scale (resolved, not resolved, dead) at day 14 and day 21. 2. Illness severity: 2.1. In adults: 2.1.1. Ambulatory Simplified Acute Physiologic Score (ASAPS) and modified ASAPS (using ACVPU instead of Glasgow) at days 0, 7, 14 and 21. 2.1.2. Quick Sepsis Related Organ Failure Assessment (qSOFA) at days 0, 7, 14 and 21. 2.2. In children <5 years is measured using the ALgorithm for the MANAgement of Childhood illness (ALMANACH) criteria at days 0, 7, 14 and 21. 3. The proportion of subjects admitted to hospital is measured at day 21. 4. Length of stay in hospital (Initial and/or secondary hospitalization) is measured at day 21. 5. Number of secondary visits is measured at day 21. 6. Number and type of laboratory and radiology tests prescribed/actually performed measured at day 21. 7. Number and type of medications and supportive care prescribed/actually given measured at day 21. 8. Working diagnoses at admission and final diagnoses measured at day 21. 9. Patient satisfaction is measured using a questionnaire at day 21.	—

Measure

Time frame

1. Clinical status is measured using a three-category ordinal scale (resolved, not resolved, dead) at day 14 and day 21. 2. Illness severity: 2.1. In adults: 2.1.1. Ambulatory Simplified Acute Physiologic Score (ASAPS) and modified ASAPS (using ACVPU instead of Glasgow) at days 0, 7, 14 and 21. 2.1.2. Quick Sepsis Related Organ Failure Assessment (qSOFA) at days 0, 7, 14 and 21. 2.2. In children <5 years is measured using the ALgorithm for the MANAgement of Childhood illness (ALMANACH) criteria at days 0, 7, 14 and 21. 3. The proportion of subjects admitted to hospital is measured at day 21. 4. Length of stay in hospital (Initial and/or secondary hospitalization) is measured at day 21. 5. Number of secondary visits is measured at day 21. 6. Number and type of laboratory and radiology tests prescribed/actually performed measured at day 21. 7. Number and type of medications and supportive care prescribed/actually given measured at day 21. 8. Working diagnoses at admission and final diagnoses measured at day 21. 9. Patient satisfaction is measured using a questionnaire at day 21.

—

Countries

Cameroon, Central African Republic, Côte d'Ivoire, Gambia, Ghana, Guinea, Madagascar, Nigeria, Senegal, Tanzania, Uganda

Contacts

Public ContactAnani Badje

anani.badje@gmail.com+225 40732415

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 13, 2026