Collaborative randomised controlled trial of trigger versus conventional ventilation in preterm infants with respiratory distress syndrome

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN53727120

Enrollment

924

Registered

2004-01-23

Start date

1994-11-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neonatal diseases Neonatal Diseases Respiratory distress syndrome of newborn

Interventions

1. Trigger ventilation 2. Conventional ventilation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Infants of less than 32 weeks gestation, they are ventilated within 72 hours of birth, and have features compatible with respiratory distress syndrome

Exclusion criteria

Exclusion criteria: Babies with evidence of major congenital malformation or evidence of inhalational pneumonitis will be excluded

Design outcomes

Primary

Measure	Time frame
1. Death before discharge home or oxygen therapy at 36 weeks gestation 2. Pneumothorax whilst ventilated 3. Cerebral ultrasound abnormality nearest 6 weeks 4. Duration of ventilation in survivors	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026