Perfusion index derived from a pulse oximeter to predict fluid responsiveness in patients with acute circulatory failure in the intensive care unit

Changes in the plethysmographic perfusion index to detect fluid responsiveness in spontaneously ventilated patients

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN53719438

Enrollment

Registered

2021-05-20

Start date

2021-04-01

Completion date

Unknown

Last updated

2021-06-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with acute circulatory failure Circulatory System

Interventions

Baseline data will be collected from all patients in a semi-fowler position (head between 30-35°). Which include demographic characteristics and hemodynamic measurements (changes in perfusion index an

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age greater than or equal to 18 years 2. With spontaneous ventilation 3. Patients with acute circulatory failure, defined as: 3.1. Hypotension (systolic blood pressure <90 mmHg and/or mean arterial pressure <65 mmHg, or drop in mean arterial pressure =40 mmHg from baseline), and/or 3.2. Use of vasopressors, associated with: 3.3. Signs of hypoperfusion (altered mental state, oligoanuria, lactate greater than or equal to 2 mmol/L, clinical skin changes associated with hypoperfusion)

Exclusion criteria

Exclusion criteria: 1. Presence of atrial fibrillation 2. Invasive mechanical ventilation in controlled modalities 3. Situations in which a passive leg raising maneuver is contraindicated (head trauma, deep vein thrombosis in the pelvic limbs, intra-abdominal hypertension> 12 mmHg) 4. Patients with a poor echocardiographic window and in whom an adequate 5-chamber apical window cannot be obtained 5. Patients whose echocardiogram shows aortic stenosis and insufficiency

Design outcomes

Primary

Measure	Time frame
Perfusion index and velocity integral time will be measure at baseline (time 0), after a passive leg-raising maneuver (time 1), and semi-fowler position after 2 minutes (time 2). (The changes of the (perfusion index) PI and (velocity integral time) VTI will be represented in relative changes: [PI before the maneuver (time 0) - PI after the maneuver (time 1)] / PI before the maneuver (time 0) x 100 and, [VTI before the maneuver (time 0) - VTI after the maneuver (time 1)] / IVT before the maneuver (time 0) x 100 respectively. A passive leg-raising maneuver will be defined as positive when an increase in VTI greater than or equal to 15%.)	—

Measure

Time frame

Perfusion index and velocity integral time will be measure at baseline (time 0), after a passive leg-raising maneuver (time 1), and semi-fowler position after 2 minutes (time 2). (The changes of the (perfusion index) PI and (velocity integral time) VTI will be represented in relative changes: [PI before the maneuver (time 0) - PI after the maneuver (time 1)] / PI before the maneuver (time 0) x 100 and, [VTI before the maneuver (time 0) - VTI after the maneuver (time 1)] / IVT before the maneuver (time 0) x 100 respectively. A passive leg-raising maneuver will be defined as positive when an increase in VTI greater than or equal to 15%.)

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Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

Mexico

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026