Breast cancer Cancer Malignant neoplasm of breast
Conditions
Interventions
Study design:
These are single-centre non-blinded randomised cross-over trials (RCT) comparing i) treatment in voluntary deep inspiartor breath-hold (v_DIBH) versus Active Breathing Co
Sponsors
The Royal Marsden Foundation Trust (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Complete microscopic excision of early stage invasive ductal or lobular carcinoma (pT1-3b N0-1 M0) of the left breast following breast conservation surgery or mastectomy 2. Recommendation for whole breast (Group A and B) or chest wall radiotherapy (Group A only) (with or without tumour bed boost) 3. Age =18 4. Performance status =1 5. Patients able to tolerate breath-ho 6. Target Gender: Female 7. Lower Age Limit is 18 years
Exclusion criteria
Exclusion criteria: 1. Requirement for nodal irradiaion 2. Patients with micro- or macro-scopic disease on sentinel node biopsy who have not undergone completion axillary node clearance 3. Previous radiotherapy to any region above the diaphragm
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Group B: Difference in mean LAD NTDmean - difference in mean normal tissue dose (NTDmean) (Gy) to left anterior-descending coronary artery | — |
Primary
| Measure | Time frame |
|---|---|
| Group A: Reproducibility - interfraction reproducibility of patient position (mean daily displacements of chest wall) in v_DI | — |
Countries
United Kingdom
Outcome results
None listed