Early initiation of gonadotropin-releasing hormone (GnRH) antagonist during assisted reproductive technology (ART)

Controlled ovarian hyperstimulation with long versus conventional protocol of gonadotropin-releasing hormone (GnRH) antagonist in women with polycystic ovarian disease (PCOD) undergoing assisted reproduction: a randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN53514546

Enrollment

140

Registered

2011-08-26

Start date

2006-01-01

Completion date

Unknown

Last updated

2017-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovarian syndrome Nutritional, Metabolic, Endocrine Polycystic ovarian syndrome

Interventions

Controlled ovarian stimulation (COS) for intracytoplasmic sperm aspiration (ICSI) procedures in infertile patients with polycystic ovarian syndrome (PCOS). Two groups were studied. The study group

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Women (age between 18-40 years) with PCOS, undergoing assisted reproductive technology (ART). PCOS was defined according to Rotterdam criteria at least 2 of the following 3 features: 1.1. Oligo and/or anovulation 1.2. Clinical and/or biochemical signs of hyperandrogenism and 1.3. Polycystic ovary on ultrasound scan (The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group 2004)

Exclusion criteria

Exclusion criteria: 1. Hypothyroidism 2. Hyperprolactinemia 3. Non-classical form of congenital adrenal hyperplasia 4. Cushing?s syndrome 5. Androgen-secreting tumors

Design outcomes

Primary

Measure	Time frame
Implantation rates evaluated at the end of the study	—

Secondary

Measure	Time frame
1. Clinical pregnancy, delivery, and miscarriage rates 2. The incidence of severe ovarian hyperstimulation syndrome (OHSS)	—

Countries

United States of America

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026