Prenatal treatment of Lower Urinary Tract Obstruction

Conditions

Congenital bladder outflow obstruction Neonatal Diseases Congenital obstructive defects of renal pelvis and congenital malformations of ureter

Morris RK, Malin GL, Quinlan-Jones E, Middleton LJ, Diwakar L, Hemming K, Burke D, Daniels J, Denny E, Barton P, Roberts TE, Khan KS, Deeks JJ, Kilby MD.

2013-12-0140 citations

10.3310/hta17590

Percutaneous vesicoamniotic shunting versus conservative management for fetal lower urinary tract obstruction (PLUTO): a randomised trial.

Morris RK, Malin GL, Quinlan-Jones E, Middleton LJ, Hemming K, Burke D, Daniels JP, Khan KS, Deeks J, Kilby MD, Percutaneous vesicoamniotic shunting in Lower Urinary Tract Obstruction (PLUTO) Collaborative Group.

2013-08-14183 citations

10.1016/s0140-6736(13)60992-7

Interventions

Fetal vesico-amniotic shunt versus no shunt.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Mother: 1. Written informed consent given 2. Able to understand information provided (use of interpreter may be required) 3. Singleton pregnancy Foetus: 1. Evidence of bladder outflow obstruction from ultrasound imaging 2. No major extra genitourinary anomalies present

Exclusion criteria

Exclusion criteria: Additional major structural or chromosomal anomaly

Design outcomes

Primary

Measure	Time frame
Perinatal mortality rates and renal function at 4 - 6 weeks and 12 months measured via: 1. Serum creatinine 2. Renal ultrasound 3. Need for dialysis/transplant	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed