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Cognitive-behavioural therapy for treatment-resistant depression: early intervention study

Cognitive-behavioural therapy for treatment-resistant depression: early intervention study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN53305823
Enrollment
24
Registered
2007-09-28
Start date
2006-05-01
Completion date
Unknown
Last updated
2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression Mental and Behavioural Disorders Depressive episode

Interventions

Patients are randomised to: 1. CBT 2. Treatment-as-usual Face to face interviews and video recording will also take place.

Sponsors

Record Provided by the NHSTCT Register - 2007 Update - Department of Health
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 24 depressed NHS patients, aged 18 - 65 years, will be recruited from routine referrals to the Newcastle CBT Centre (NCBTC) and secondary care mental health services within the 3Ns Trust. Inclusion criteria: 1. Adults aged 18 - 65 years 2. Major depressive episode as the primary diagnosis, first or second major episode, lasting at least 12 months duration 3. Moderate or severe depression symptoms 4. Treatment-resistance to at least one course of anti-depressant previously administered at an adequate dose for adequate period, treatment resistance to other primary care interventions

Exclusion criteria

Exclusion criteria: 1. Previous individual or group CBT following a recognised protocol within secondary care services 2. Three or more major episodes of depression 3. People with bi-polar disorder, psychosis, learning disability, borderline personality disorder, alcohol or addiction problems

Design outcomes

Primary

MeasureTime frame
1. CORE 2. Hamilton Depression Scale (HAM-D) 3. Beck Depression Inventory (BDI) 4. Beck Hopelessness Scale (BHS)

Secondary

MeasureTime frame
1. Quality of Life and Social Functioning: to be determined through discussion with Psychological Therapies Research Network 2. Mediating Variables: Dysfunctional Attitudes Scale (DAS), Automatic Thoughts Questionnaire (ATQ), Sentence Completion Test for Depression (SCD), Roles and Goals Questionnaire (RAG).

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026