Multi-vessel coronary heart disease with diseased LAD requiring surgery Circulatory System Coronary heart disease
Conditions
Interventions
1. Hybrid group: surgical revascularisation of LAD with left Arteria thoracica interna-Bypass supply of dominant not interventional treatable vessels by off-pump technique.
2. Conventionally treated g
Sponsors
Martin Luther-University Halle-Wittenberg (Germany)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Coronary heart disease with diseased Left Anterior Descending coronary artery (LAD) requiring surgery 2. Male or female patients with 75 years of age or older in therapy groups 3. Male or female patients with 60 years of age or less in consecutive observed younger patients (control group) 4. Signed and dated informed consent
Exclusion criteria
Exclusion criteria: 1. Combined surgery (heart valve plus bypass) 2. Emergency treatment along with unstable cardiovascular system 3. Known intolerability of AcetylSalicylic acid (ASS), Clopidogrel and other concomitant medication required for stent-implantation 4. Participation on other clinical trials 5. Situations that limit the compliance with study requirements
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of post-operative complications (organ insufficiencies, stroke, myocardial infarction, symptomatic transitory psychotic syndrome, infection, shock, multiple systems organ failure, death) during hospitalisation. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Lethality and therapy costs during hospitalisation and in the first post-operative year 2. Survival after six and 12 month 3. Rates of complications (see primary outcomes) 4. Post-operative quality of life (Short Form health survey [SF-36], Hospital Anxiety and Depression Scale [HADS]) 5. Occurrence of postoperative complications in the group of consecutive observed younger patients (control group) | — |
Countries
Germany
Outcome results
None listed