Low dose inhaled nitric oxide in patients with acute lung injury

Low dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN53268296

Enrollment

385

Registered

2012-01-31

Start date

1996-03-27

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute lung injury Injury, Occupational Diseases, Poisoning Other injuries of lung

Interventions

Inhaled nitric oxide (5ppm) or placebo (nitrogen gas) is delivered with mechanical ventilator breaths until the patient is extubated or for a total of 28 days.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Mechanically ventilated patients with acute lung injury 2. Ratio of partial pressure of arterial oxygen (O2) to the fraction of inspired partial pressure of oxygen in arterial blood/fraction of inspired oxygen (Pa02/FiO2) ratio of 250 or less

Exclusion criteria

Exclusion criteria: Sepsis as the cause of the acute lung injury

Design outcomes

Secondary

Measure	Time frame
Pulmonary function including spirometry, lung volumes and diffusion of carbon monoxide evaluated at 6 months	—

Primary

Measure	Time frame
Days alive and off mechanical ventilation	—

Countries

United States of America

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 24, 2026