A randomised trial of conventional and off-pump coronary artery bypass grafting (CABG) on myocardial injury as assessed by multi-parametric magnetic resonance imaging (MRI) and specific biochemical markers.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN53238725

Enrollment

Registered

2005-09-30

Start date

2002-06-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery: Coronary artery bypass grafting (CABG) Surgery

Interventions

Patients will be randomised to receive conventional CABG or off-pump CABG (OPCABG).

Eligibility

Inclusion criteria

Inclusion criteria: 90 patients undergoing CABG

Exclusion criteria

Exclusion criteria: Does not match inclusion criteria

Design outcomes

Primary

Measure	Time frame
1. Number and percentage of new left ventricular (LV) wall segments that are assessed as non viable by late Gd-DTPA MR imaging in both the conventional CABG and OPCABG groups 2. The distribution (regional versus global) of new non viable LV segments in both the conventional CABG and OPCABG groups 3. The extent of post operative rise in biochemical cardiac markers will be compared in the two surgical groups and will be correlated with the functional cardiac MR assessment.	—

Measure

Time frame

1. Number and percentage of new left ventricular (LV) wall segments that are assessed as non viable by late Gd-DTPA MR imaging in both the conventional CABG and OPCABG groups 2. The distribution (regional versus global) of new non viable LV segments in both the conventional CABG and OPCABG groups 3. The extent of post operative rise in biochemical cardiac markers will be compared in the two surgical groups and will be correlated with the functional cardiac MR assessment.

—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026