Hepatocellular carcinoma/portal vein tumour thrombus Cancer Hepatocellular carcinoma
Conditions
Interventions
1. Intervention: percutaneously implant the sustained release particle of 5-fluorouracil in the tumour thrombus and treat HCC with TAC
2. Control: single treatment of HCC with TAC
For the interventio
Sponsors
Affiliated 10th People's Hospital of Tongji University (China)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Image-proven HCC 2. Irresectable tumour 3. Failure to previous treatment 4. Child-Pugh scale less than or equal to 10 5. Aged 30 - 80 years, either sex 6. Tumour thrombus is proven within portal vein and its section area exceeds 50% of vessel by computed tomography (CT)
Exclusion criteria
Exclusion criteria: 1. Uncontrolled hypertension 2. Unstable angina 3. Arrhythmias requiring treatment 4. Myocardial infarction (MI) 5. Congestive heart failure or cardiomyopathy requiring treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Patient dies, measured at one month and six months 2. Disappearance of portal vein thrombus, measured at one month | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Closure of portal vein lateral flow, measured at one and two months 2. Decreased size of thrombus less than or equal to 20% of original, measured at one month, two months, four months and six months | — |
Countries
China
Outcome results
None listed