Skip to content

Study to assess the effectiveness and mechanism of change of group interpersonal therapy for depressed adolescents in Nepal

School-based group interpersonal therapy for adolescents with depression in Nepal: A phase III realist cluster-randomised controlled trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN52852397
Enrollment
1576
Registered
2025-03-21
Start date
2025-04-01
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Treatment of depressive symptoms among school-going adolescents in Nepal Mental and Behavioural Disorders

Interventions

Participants in the intervention arm will receive group interpersonal therapy in schools facilitated by trained laypersons. Groups are gender specific and comprise 5-8 adolescents. There are two pre-g

Sponsors

University College London
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Adolescents: 1. 13-19 years old 2. Attending a participating school 3. Going to grades 7, 8, or 9 4. With depression assessed using a standardised tool (=10 for the PHQ-A) Caregivers: 1. 18 years old and above 2. Being a caregiver (e.g, parent, grandparent, family member) of an adolescent who takes part in the study IPT facilitators and supervisors: 1. 18 years old and above 2. Being an IPT facilitator or supervisor in this trial School staff: 1. 18 years old and above 2. Working at schools that participated in the trial or working in a school within the same municipality

Exclusion criteria

Exclusion criteria: Adolescents: We will exclude participants who are currently at risk for suicide. High risk for suicide includes a) suicide ideation with a plan in the past 2 weeks, b) suicide attempt in the past three months and c) lifetime suicide attempt with suicidal ideation in the past 2 weeks. Caregivers: No exclusion criteria IPT facilitators and supervisors: No exclusion criteria School staff: No exclusion criteria

Design outcomes

Primary

MeasureTime frame
Depressive symptoms measured using the Patient Health Questionnaire modified for adolescents (PHQ-A) at endline

Secondary

MeasureTime frame
1. Functional impairment measured using a tool developed for the study setting at endline 2. Anxiety symptoms measured using the Generalised Anxiety Disorder Assessment (GAD-7) at endline 3. Post-traumatic stress disorder symptoms measured using the PCL-5 8-items at endline 4. School attendance calculated as the percentage of days attended in a standardised four-week period (excluding school closures) at endline 5. Academic performance in a standardised exam at follow-up

Countries

Nepal

Contacts

Public ContactKelly Rose-Clarke
kelly.rose-clarke@ucl.ac.uk+44 (0) 20 7679 2000

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026