Acute Kidney Injury Urological and Genital Diseases
Conditions
Interventions
We randomly assigned critically ill patients with AKI to receive higher or lower intensity PD therapy. A PD session was defined as 24 h of dialysis with sessions performed 7 days per week. Peritoneal
Sponsors
São Paulo State University (Universidade Estadual Paulista [UNESP]) (Brazil)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adults with Acute Kidney Injury (AKI) according to Acute Kidney Injury Network (AKIN) criteria 2. Clinical diagnosis of severe acute tubular necrosis (ATN) caused by a recent ischemic or nephrotoxic injury. Severe ATN was defined as a history of prolonged and profound hypotension, severe nephrotoxic drugs overdose, or excess endogenous nephrotoxic pigments (hemoglobinuria, myoglobinuria). Diagnosis was based on clinical history, results of physical examination, relevant blood tests, and urinalysis (microscopical examination of urinary sediment), a fractional excretion of sodium that exceeded 1% and the findings on renal ultrasonography.
Exclusion criteria
Exclusion criteria: 1. Under 18 years of age 2. Functional azotemia 3. Urinary tract obstruction 4. Acute interstitial nephritis 5. Rapidly progressive glomerulonephritis 6. History of chronic renal insufficiency (serum creatinine 43mg per 100 ml) 7. Renal transplantation 8. Pregnancy 9. Severe hypercatabolism according to Scherier criteria 10. Absolute contraindication for PD were recent abdominal surgery (less than one month) 11. Multiple abdominal surgeries (more than three) 12. Patients submitted to less than one session of high volume PD (HVPD), defined as 24 h.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Death within 30 days | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Recovery of kidney function within 30 days 2. Metabolic control | — |
Countries
Brazil
Outcome results
None listed