Corneal graft rejection Injury, Occupational Diseases, Poisoning Failure and rejection of transplanted organs and tissues
Conditions
Interventions
After corneal transplantation surgery, patients in the study group will receive 2% ciclosporin eye drops prepared in 1.4% polyvinyl alcohol every six hours for one year. Patients in the control group
Sponsors
Indian Council of Medical Research (ICMR) (India)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients greater than or equal to 9 years of age, either sex 2. Eyes undergoing penetrating keratoplasty 3. With two or more quadrants of corneal vascularisation extending at least 2 mm into the cornea 4. Cases of corneal re-grafts
Exclusion criteria
Exclusion criteria: 1. Grafts that are not high-risk 2. Pregnant/lactating females 3. Children below 9 years of age 4. Patients who refused to give consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of occurrence of corneal endothelial graft rejection after high-risk keratoplasty in the study and control group at the end of one year. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Incidence of reversal of graft rejection in the study and control group at the end of one year 2. Incidence of occurrence possible side effects of using ciclosporin A eye drops in the study group at the end of one year | — |
Countries
India
Outcome results
None listed