Hyperemesis gravidarum Pregnancy and Childbirth Excessive vomiting in pregnancy
Conditions
Interventions
Metoclopramide (10 mg) or prochlorperazine (12.5 mg) intravenously 8-hourly for 24 hours.
Sponsors
University of Malaya (Malaysia)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Females aged over 16 years 2. First hospitalisation for hypermesis gravidarum in current pregnancy 3. Gestation less than 20 weeks 4. Clinically dehydrated with ketonuria
Exclusion criteria
Exclusion criteria: 1. Multiple gestation 2. Proven non viable pregnancy 3. Pre-existing medical condition that can cause nausea and vomiting, e.g.: 3.1. Concomitant confounders of severity of nausea and vomiting, e.g., culture proven symptomatic urinary tract infection, dengue fever 3.2. Gastrointestinal causes of vomiting, e.g., gastro-enteritis 3.3. Medical causes of vomiting e.g. diabetic ketoacidosis 3.4. Allergies to metoclopramide or prochlorperazine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Satisfaction score at 24 hours using a self-administered 10 point visual numerical rating scale (VNRS) 2. Frequency of vomiting during the 24 hours study period | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Nausea scores measured using a 10 point VNRS at enrolment, 8 hours, 16 hours and 24 hours 2. Ketonuria status at the end of study period 3. Addition or change of anti-emetic required during the study period 4. Admission to discharge interval 5. Time to discontinuation of IV fluids 6. Time to discontinuation of IV anti-emetics 7. Any adverse events 8. Self administered side effects profile at end of study period - symptoms of: 8.1. Drowsiness 8.2. Inability to sleep 8.3. Dry mouth 8.4. Dizziness 8.5. Diarrhoea 8.6. Headache 8.7. Palpitations 8.8. Uncontrollable movements or muscle spasms 8.9. Rash | — |
Countries
Malaysia
Outcome results
None listed