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Assessment of cerebral oxygen supply-demand balance by near-infrared spectroscopy during induction of anesthesia in patients undergoing coronary artery bypass graft surgery: Comparison of midazolam with propofol

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN52666802
Enrollment
60
Registered
2008-02-27
Start date
2006-08-31
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery bypass graft surgery Circulatory System Coronary artery bypass graft surgery

Interventions

Upon arrival at the operating room, standard monitoring devices were applied and a radial artery catheter was inserted under local anaesthesia for continuous blood pressure monitoring. Also, a pulmona
BIS) (A-2000TM, Aspect Medical Systems, USA) and rSO2 (INVOS 5100TM, Somanetics, USA) were continuously monitored with both sensors applied to the forehead of the patients. Hemodynamic variables, BI

Sponsors

Yonsei University, College of Medicine (Korea, South)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Adult patients admitted to the Yonsei University Health System scheduled for isolated off-pump coronary artery bypass graft surgery between August 2006 and March 2007.

Exclusion criteria

Exclusion criteria: 1. Patients undergoing emergent surgery 2. Pre-existing neurologic disease 3. Lung parenchymal disease 4. New York Heart Association (NYHA) functional class >= 3 5. Left ventricular ejection fraction <40% 6. Unstable angina and recent myocardial infarction within 1 month 7. Patients who had significant luminal narrowing of either carotid and/or vertebral arteries on preoperative angiography

Design outcomes

Primary

MeasureTime frame
Regional cerebral oxygen saturation measured by near infrared spectroscopy

Secondary

MeasureTime frame
Hemodynamic variables including the following: 1. Cardiac index (CI) 2. Mixed venous oxygen saturation 3. Mean arterial pressure 4. Central venous pressure

Countries

Korea, South

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026