Cutaneous vascular reactivity and flow motion response to vasopressin in advanced vasodilatory shock and severe postoperative multiple organ dysfunction syndrome

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN52577337

Enrollment

Registered

2005-10-21

Start date

2004-01-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe multiple organ dysfunction syndrome Injury, Occupational Diseases, Poisoning Multiple organ failure

Interventions

NE plus supplementary AVP (Pitressin®

Pfizer, Karlsruhe, Germany) infused at a continuous rate of 4 IU/hour versus NE alone.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Critically ill patients suffering of severe multiple organ dysfunction syndrome after cardiac or major surgery with a mean arterial blood pressure less than 65 mmHg despite adequate volume resuscitation, and Norepinephrine (NE) requirements greater than 0.5 µg/kg/min.

Exclusion criteria

Exclusion criteria: Patients with arterial vascular occlusive disease or insulin-dependent diabetes mellitus.

Design outcomes

Primary

Measure	Time frame
Differences in the area under the concentration-time Area Under Curve (AUC) of the Doppler signal and the reactive hyperemic response to forearm ischaemia between AVP/NE and NE patients.	—

Secondary

Measure	Time frame
Differences in the oscillation frequency of the Doppler signal between groups.	—

Countries

Austria

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026