Fluid restriction following open aortic aneurysm surgery

Does peri-operative fluid restriction affect renal function following major abdominal aortic surgery? A single-centre randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN52446152

Enrollment

Registered

2010-07-14

Start date

2010-02-01

Completion date

Unknown

Last updated

2017-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elective infra-renal aortic aneurysm surgery Surgery Aortic aneurysm surgery

Interventions

The intervention group will have a fluid-restricted regime of 1.5 l intravenous (IV) fluid per day post-operatively compared to 3 l in the standard regime group. Of course, there is provision for flui

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Elective patients (aged over 18 years, either sex) undergoing open infra-renal abdominal aortic aneurysm (AAA) repair

Exclusion criteria

Exclusion criteria: 1. Patients undergoing endovascular aortic aneurysm repair 2. Patients undergoing emergency surgery 3. Elective suprarenal AAA repair 4. Severe cardiac failure (New York Heart Association [NYHA] grade IV or myocardial infarction [MI] less than 3 months) 5. Pre-operative serum creatinine greater than 150 mg/dL 6. Pre-operative serum urea greater than 20 mmol/dl 7. Previous history of renal disease 8. Previous renal transplant 9. Patient scheduled to have simultaneous renal procedure at time of surgery 10. Established renal failure requiring renal replacement therapy 11. Previous history of hepatic disease

Design outcomes

Primary

Measure	Time frame
Urinary levels of interleukin-18 (IL-18), neutrophil gelatinase-associate lipocalin (NGAL), retinol binding protein (RBP), albumin/creatinine ratio (ACR), measured at baseline (pre-operative), 6 hours, 12 hours, 24 hours, day 2 ,day 3, day 4, day 5	—

Secondary

Measure	Time frame
All measured as inpatient outcomes: 1. All major complications 2. Major adverse cardiac event (myocardial infarction, unstable angina, arrhythmia) 3. Respiratory complications (including need, duration and extent of ventilatory support) 4. Neurological complications (delirium, stroke) 5. Mortality 6. Length of stay 7. Intensive care unit (ITU)/high dependency unit (HDU) stay 8. Wound dehiscence 9. Gastrointestinal outcome measures: 9.1. Time to passage of first flatus 9.2. Time to passage of first faeces 9.3. Nausea scores 9.4. Time to resumption of normal diet	—

Measure

Time frame

All measured as inpatient outcomes: 1. All major complications 2. Major adverse cardiac event (myocardial infarction, unstable angina, arrhythmia) 3. Respiratory complications (including need, duration and extent of ventilatory support) 4. Neurological complications (delirium, stroke) 5. Mortality 6. Length of stay 7. Intensive care unit (ITU)/high dependency unit (HDU) stay 8. Wound dehiscence 9. Gastrointestinal outcome measures: 9.1. Time to passage of first flatus 9.2. Time to passage of first faeces 9.3. Nausea scores 9.4. Time to resumption of normal diet

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Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026