Can the presence of insecticide treated materials in the household control dengue vectors?

A cluster randomised controlled trial of household-based insecticide treated window curtains and water jar covers for control of the dengue vector Aedes aegypti in the community

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN52339690

Enrollment

7500

Registered

2010-03-18

Start date

2006-07-01

Completion date

Unknown

Last updated

2020-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dengue (including Dengue Haemorrhagic Fever [DHF] and Dengue Shock Syndrome [DSS]) Infections and Infestations Dengue fever [classical dengue]

Interventions

Curtains made from deltamethrin-coated polyester netting (Long Lasting Impregnated netting

PermaNet® Vestergaard-Frandsen, Lausanne, Switzerland), hung in all outer windows regardless of the presence or absence of other window coverings (World Health Organization Pesticide Evaluation Scheme

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All occupied households

Exclusion criteria

Exclusion criteria: 1. Business-only premises 2. Multi-storey buildings

Design outcomes

Primary

Measure	Time frame
Entomological outcomes, the standard larval indices for the Aedes aegypti mosquito vector of dengue: 1. Breteau index: number of containers with immature stages per 100 houses 2. House index: number of houses containing immature stages per 100 houses 3. Container index: number of containers with immature stages per 100 containers with water 4. Pupal surveys were also undertaken to calculate the number of pupae per person index (number of pupae collected/human population in a sector) Follow up surveys made to all houses at 1, 18, 24, 26 months post-intervention. Analyses to measure impact of the intervention on dengue vector populations will be undertaken according to intention to treat and per protocol (based on extent of coverage as determined in follow-up surveys).	—

Measure

Time frame

Entomological outcomes, the standard larval indices for the Aedes aegypti mosquito vector of dengue: 1. Breteau index: number of containers with immature stages per 100 houses 2. House index: number of houses containing immature stages per 100 houses 3. Container index: number of containers with immature stages per 100 containers with water 4. Pupal surveys were also undertaken to calculate the number of pupae per person index (number of pupae collected/human population in a sector) Follow up surveys made to all houses at 1, 18, 24, 26 months post-intervention. Analyses to measure impact of the intervention on dengue vector populations will be undertaken according to intention to treat and per protocol (based on extent of coverage as determined in follow-up surveys).

—

Secondary

Measure	Time frame
1. Seroconversion rates (as measured by IgM ELISA) in households in the treated and control sectors compared at baseline and at the trial's end. Members of each household between 2 - 8 years of age specifically selected for the study. 2. Interview surveys used to determine: 2.1. Household characteristics 2.2. Previous vector control intervention 2.3. Better understanding of the local population's knowledge, attitudes and practice about previous methods of dengue prevention and control, and about ITMs for the same purpose 3. Insecticide-susceptibility assays undertaken before, at follow-up surveys and after intervention Each house was also georeferenced with a handheld global positioning system receiver to permit subsequent overspill effects between adjacent treated and control clusters to be quantified.	—

Measure

Time frame

1. Seroconversion rates (as measured by IgM ELISA) in households in the treated and control sectors compared at baseline and at the trial's end. Members of each household between 2 - 8 years of age specifically selected for the study. 2. Interview surveys used to determine: 2.1. Household characteristics 2.2. Previous vector control intervention 2.3. Better understanding of the local population's knowledge, attitudes and practice about previous methods of dengue prevention and control, and about ITMs for the same purpose 3. Insecticide-susceptibility assays undertaken before, at follow-up surveys and after intervention Each house was also georeferenced with a handheld global positioning system receiver to permit subsequent overspill effects between adjacent treated and control clusters to be quantified.

—

Countries

Venezuela

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026