Parkinson's disease, exercise and cognitive training

Effects of the combination of physical exercise and cognitive training on cognitive functions in patients with Parkinson's disease

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN52284448

Enrollment

Registered

2016-04-14

Start date

2016-06-01

Completion date

Unknown

Last updated

2018-02-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease Nervous System Diseases Parkinson's disease

Interventions

Patients will be allocated randomly in two groups, a group of multimodal intervention (physical exercise + cognitive training) and a group of unimodal intervention (cognitive training). Group 1: Part

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 40–80 years 2. Diagnosed with PD according to UK PD Society Brain Bank Criteria.26 3. Disease severity of Hoehn and Yahr (H&Y) stages I–III

Exclusion criteria

Exclusion criteria: 1. Significant cognitive impairment (Mini-Mental State Examination 10) 4. Severe auditory or visual deficits 5. Another psychiatric/neurological condition

Design outcomes

Primary

Measure	Time frame
1. Cognitive performance is measured using CDS (Cognitive Difficulties Scale), WAIS-III (Wechsler Adult Intelligence Scale-III), Digital Span Forward and backwards, Trail Making Test A and B, Stroop Test, Corsi Block, Verbal Fluency (FAS), Tower of London and Wilcoxin Card Sorting Test at 2 month before intervention, 2 weeks before intervention (baseline), 2 weeks post-intervention and two months post-intervention (follow-up) 2. Motor performance is measured using walk at comfortable speed, Time Up & Go and walk with dual-task at 2 month before intervention, 2 weeks before intervention (baseline), 2 weeks post-intervention and two months post-intervention (follow-up) 3. Quality of life is measured using ADLS (Activities of Dayly Living Scale), QOLS (Quality Of Life Scale) and IPAQ (International Physical Activity Questionnaire) at 2 month before intervention, 2 weeks before intervention (baseline), 2 weeks post-intervention and two months post-intervention (follow-up)	—

Measure

Time frame

1. Cognitive performance is measured using CDS (Cognitive Difficulties Scale), WAIS-III (Wechsler Adult Intelligence Scale-III), Digital Span Forward and backwards, Trail Making Test A and B, Stroop Test, Corsi Block, Verbal Fluency (FAS), Tower of London and Wilcoxin Card Sorting Test at 2 month before intervention, 2 weeks before intervention (baseline), 2 weeks post-intervention and two months post-intervention (follow-up) 2. Motor performance is measured using walk at comfortable speed, Time Up & Go and walk with dual-task at 2 month before intervention, 2 weeks before intervention (baseline), 2 weeks post-intervention and two months post-intervention (follow-up) 3. Quality of life is measured using ADLS (Activities of Dayly Living Scale), QOLS (Quality Of Life Scale) and IPAQ (International Physical Activity Questionnaire) at 2 month before intervention, 2 weeks before intervention (baseline), 2 weeks post-intervention and two months post-intervention (follow-up)

—

Secondary

Measure	Time frame
1. Functional connectivity is measured using evoked related potentials at 2 weeks before intervention (baseline) and 2 weeks post-intervention 2. White matter is measured using diffusion tensor imaging at 2 weeks before intervention (baseline) and 2 weeks post-intervention	—

Countries

Spain

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026