Diagnosis of sarcoma in adults Cancer
Conditions
Interventions
Participants will have one tissue sample collected, either from an additional core biopsy taken at the time of diagnosis, or via sampling of the surgically resected lesion at the time of its excision.
Sponsors
University of Nottingham
Eligibility
Sex/Gender
All
Age
18 Years to 110 Years
Inclusion criteria
Inclusion criteria: 1. Considered to have sarcomatous soft-tissue lesion requiring biopsy or surgical excision 2. A good comprehension of the English language 3. Age =18 years old 4. Ability to give informed consent
Exclusion criteria
Exclusion criteria: 1. Patients in which the usual care team believe the lesion to have low risk of malignancy (i.e., most likely a benign lesion based on clinical history, examination and investigation findings)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of sarcoma diagnoses correctly predicted by methylation-based classification, at 12 months post-biopsy or surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of sarcomas in which known pathognomonic molecular features are correctly identified by nanopore long-read sequencing, at 12 months post-biopsy or surgery | — |
Countries
England, United Kingdom
Contacts
Public ContactChristopher Deacon
Outcome results
None listed