Surgery: Total knee replacement (TKR) Surgery Total knee replacement (TKR)
Conditions
Interventions
The primary aim of this study is to determine if there is a difference, as measured by a decrease in morphine consumption, between two forms of lumbar plexus block in combination with or without a sci
Sponsors
Record Provided by the NHSTCT Register - 2006 Update - Department of Health
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. All patients over the age of 18 undergoing total knee replacement (TKR) at the Addenbrookes NHS Trust 2. American Society of Anesthesiologists (ASA) physical status I - III
Exclusion criteria
Exclusion criteria: 1. ASA IV and V 2. Age: less than 18 years old. There is no upper limit 3. Inability to use a PCA (Dementia, psychiatric problems, intellectual disability). A morphine PCA is the best way to monitor the use of morphine in the study. 4. Contraindication to non-steroidal anti-inflammatory (NSAIDs) (asthmatics with significant sensitivity to aspirin, renal impairment, severe liver dysfunction, history of gastric ulceration or bleeding). NSAIDs are a useful adjunct to pain relief and are necessary to be prescribed in the study. 5. Opioid dependence or chronic pain syndromes. The morphine use in this group would be difficult to interpret and may skew the data. 6. Contraindication to neuro-axial blockade or regional techniques; bleeding diathesis, anti-coagulation, absolute LA allergy, localized infection or relative contraindications of concurrent peripheral neuropathy or nerve injury. 7. Use concurrently of any other regional technique (such as spinal anaesthesia, epidural). These would interfere with the primary aim, that is, we are comparing nerve blocks not in conjunction with spinal or epidural anesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A reduction in postoperative morphine usage, as measured by morphine PCA, by 30% when compared to 'femoral sheath' block without sciatic nerve block. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed