Catheter-related bacteraemia Infections and Infestations Other septicaemia
Conditions
Interventions
Patients will randomised to receive either taurolidine-citrate or standard heparin (5000 IU/ml) line locks at the time of catheter insertion and after every dialysis until an end-point of the trial. T
Sponsors
Lancashire Teaching Hospitals NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adult patients (aged greater than 18 years), either sex 2. Requirement for dialysis using a tunnelled dialysis line 3. Able to give informed consent
Exclusion criteria
Exclusion criteria: 1. Children aged less than 18 years 2. Unable to give informed consent 3. Positive blood culture in previous seven days 4. Unstable bleeding diathesis or hypercoagulable state
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. 'Intention to treat' analysis of symptomatic and asymptomatic bacteraemic episodes. A bacteraemic episode will be defined by a single positive blood culture. Symptoms will be judged clinically on the basis of fever or rigors associated with dialysis. Measured by a positive blood culture at the time when the patient has relevant symptoms 2. A comparison of the unassisted line patency rate between the two treatment groups. This will be based on the need for thrombolytic therapy or radiological intervention. Detected by a requirement to use of thrombolytic therapy and the date when this happened. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The type of bacterium, outcome of treatment with antibiotics and relapse rate in those patients with proven infection 2. C-reactive protein concentrations 3. Haemoglobin concentrations, measured monthly 4. Erythropoietin requirement, recorded every two weeks 5. Blood flows, recorded every two weeks 6. Electron microscopy of removed lines to look for Biofilm | — |
Countries
United Kingdom
Outcome results
None listed