Is toothpaste containing xylitol + fluoride more effective than toothpaste containing only fluoride in preventing dental caries among pre-schoolers?

A clinical trial comparing fluoride toothpaste and xylitol+fluoride toothpaste in reducing dental caries among pre-schoolers at increased risk for tooth decay: a randomised prospective trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN51682476

Enrollment

200

Registered

2012-01-06

Start date

2010-09-01

Completion date

Unknown

Last updated

2022-11-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental caries Oral Health Dental caries

Interventions

Arm 1: supervised in-class toothbrushing once/day with xylitol+1400ppm fluoride toothpaste Arm 2: supervised in-class toothbrushing once/day with 1400ppm fluoride toothpaste

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Enrolled in one of four pre-schools in Majuro, Marshall Islands 2. Under age 5 3. Parent consent to participate in the trial

Exclusion criteria

Exclusion criteria: Allergy or sensitivity to fluoride toothpaste

Design outcomes

Primary

Measure	Time frame
Total increase in the number of primary tooth surfaces with untreated dental caries from baseline to end of school year	—

Secondary

Measure	Time frame
Levels of intraoral plaque and salivary mutans streptococci (at end of school year)	—

Countries

Marshall Islands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026