Primary care Musculoskeletal Diseases Osteoporosis with pathological fracture
Conditions
Interventions
Daily oral Vitamin D/Calcium/Vitamin D and calcium in combination/placebo
Sponsors
Medical Research Council (MRC) (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 70 years or over (irrespective of sex) 2. Recent first proximal femoral or other appendicular fracture sustained in a fall or clinical vertebral fracture 3. Attending fracture clinic or hospital in-patient 4. Resident in UK 5. Able to comply with protocol (eg Mini-mental Score greater than 7) 6. Gives consent
Exclusion criteria
Exclusion criteria: 1. Multiple or high energy transfer injury 2. Inability to walk prior to presenting fracture without the support of others 3. Suffering from known malignant disease 4. Contraindication to Calcium or Vitamin D 5. Current or recent treatment with more than 200iu daily of Vitamin D, Calcium, Fluoride, Diphosphonate or Calcitonin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. New fractures, 2. Cost per avoided new fracture 3. Quality of life gain | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed