Is low intensity resistance training combined with blood flow restriction beneficial to the rehabilitation of patients with knee osteoarthritis?

Effects of low load resistance training with blood flow restriction on serum growth hormone, insulin-like growth factor-1, and testosterone in patients with mild to moderate unilateral knee osteoarthritis (OA)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN51633853

Enrollment

Registered

2022-05-16

Start date

2022-05-25

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female patients with unilateral knee osteoarthritis Musculoskeletal Diseases

Interventions

This study will recruit 18 female patients with mild to moderate unilateral knee OA, which was then followed by randomly conducting three resistance exercise tests by drawing lots: 1. A 30% 1-repetiti

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Currently experiencing objective functional limitations 2. Female aged between 40 and 70 years old 3. Symptomatic unilateral knee OA 4. Not participating in any regular resistance training.

Exclusion criteria

Exclusion criteria: 1. Health status contradicted the use of a tourniquet 2. Currently suffering from peripheral vascular disorders or any condition contradicting subjecting them to exercise training 3. High blood pressure defined by a diastolic blood pressure >100 mm Hg or resting systolic blood pressure >160 or <100 mm Hg

Design outcomes

Primary

Measure	Time frame
Blood lactate (BLA), IGF-1, GH and testosterone levels will be tested at 4-time points using blood test: before exercise, immediately after exercise, 15 minutes after exercise, and 30 minutes after exercise.	—

Secondary

Measure	Time frame
Heart rate measured using heart rate band during exercise	—

Countries

China

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026