Parkinson's disease Nervous System Diseases Parkinson disease
Conditions
Interventions
The study will take place either in the Neurosciences Ward or the Charles Wolfson clinical research facility (one floor below the ward) in the John Radcliffe University Hospital according to the patie
Sponsors
University of Oxford
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Participant is willing and able to give informed consent for participation in the study 2. Male or female, aged 18 to 80 years old 3. Diagnosed with Parkinson’s disease, essential tremor or dystonia 4. Has completed stage 1 of a two-stage surgery for deep brain stimulation as therapy for their movement disorder
Exclusion criteria
Exclusion criteria: 1. Cognitive impairment (judged by the clinician taking consent as not having sufficient mental capacity to understand the study and its requirements). This is including anyone who, in the opinion of the clinician taking consent, is unlikely to retain sufficient mental capacity for the duration of their involvement in the study 2. Intracranial bleeding, cerebrospinal fluid leak or any other complication after the first stage of surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measured before and after feedback-controlled stimulation: 1. Kinematic recordings (accelerometer and BRAIN test in all patients) related to movement speed, spasms and the presence of tremor 2. Scores on standard, disease-specific clinical rating scales (UPDRS and UDysRS in Parkinson’s disease, TETRAS in essential tremor and BFMRS and UDysRS in dystonia) and on Speech Intelligibility Test (all patients) 3. Scalp EEG (brain waves), depth EEG and EMG (muscle) recordings (all patients) | — |
Secondary
| Measure | Time frame |
|---|---|
| There are no secondary outcome measures | — |
Countries
United Kingdom
Outcome results
None listed