Coronary artery disease Circulatory System Atherosclerotic heart disease
Conditions
Interventions
Randomised controlled trial of two contrast agents, iodixanol vs iohexol.
The specific aims of this study are two-fold:
1. to obtain pilot flow cytometry data to establish whether platelets from patie
Sponsors
Centre for Health Science (UK)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Male 2. Aged 50-70 3. Clinical reason for coronary angiography 4. Coronary artery disease defined by coronary angiography 5. No history of diabetes, fasting blood glucose < 6 mmol/l, HbA1c < 6.5% 6. Taking aspirin but not clopidogrel 7. Non-smoker
Exclusion criteria
Exclusion criteria: 1. Participation in pharmacological study within last 3 months 2. Taking clopidogrel
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Assessment of platelet function and cellular oxidative stress using flow cytometry (platelet-monocyte binding, oxidative stress markers) 2. Plasma samples will be assessed for tissue plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1) to help identify whether there is any effect on fibrinolytic capacity | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To assess the ability of contrast media to generate oxygen-centred free radicals | — |
Countries
United Kingdom
Outcome results
None listed