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Immediate versus Delayed Oxytocin Following Amniotomy for labour induction

Immediate versus Delayed Oxytocin Following Amniotomy for labour induction in parous women with favourable cervixes: a double blind randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN51476259
Enrollment
206
Registered
2009-12-11
Start date
2009-11-15
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Induction of labour Pregnancy and Childbirth Other complications of labour and delivery, not elsewhere classified

Interventions

After amniotomy for labour induction: 1. Immediate oxytocin (blinded) starting at 1 mU/min (3 ml/hr, doubling in rate as required every 30 minutes to achieve 3 - 4 uterine contractions every 10 minute

Sponsors

University of Malaya (Malaysia)
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1. Females aged over 16 years 2. Planned labour induction 3. Parous (at least 1 prior vaginal birth greater than 24 weeks) 4. Term gestation (greater than 36 weeks) 5. Bishop score on recruitment greater than or equal to 6 with cervical dilation greater than or equal to 2 cm suitable for amniotomy 6. Intact membranes 7. Singleton pregnancy 8. Cephalic presentation 9. Reassuring cardiotocograph

Exclusion criteria

Exclusion criteria: 1. Previous uterine incision or injury (e.g. caesarean delivery, myomectomy, perforation) 2. Gross foetal anomaly 3. Contraindication for vaginal birth

Design outcomes

Primary

MeasureTime frame
1. Vaginal delivery within 12 hours 2. Maternal satisfaction score with the birth process (10 point visual numerical rating score VNRS)

Secondary

MeasureTime frame
1. Induction to delivery interval 2. Mode of delivery/caesarean delivery 3. Use opiate/epidural analgesia in labour 4. Prenatal oxytocin use 5. Intrapartum and postpartum fever 6. Delivery blood loss 7. Maternal antibiotic use 8. Induction to hospital discharge interval 9. Apgar Score 10. Umbilical arterial blood pH 11. Neonatal jaundice requiring phototherapy or more 12. Neonatal admission

Countries

Malaysia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 24, 2026