Osteoarthritis (OA) of the knee Musculoskeletal Diseases Osteoarthritis of the knee
Conditions
Interventions
Patients will be allocated to one of three different preparations, a cross-linked formulation
(Synvisc®) and non-cross-linked preparations of different origin (Orthovisc® and Ostenil®).
Patients will
Sponsors
Swiss Federal Office of Social Insurance (OFAS) (Switzerland)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Men and non-pregnant women with radiologically confirmed symptomatic OA of the knee for at least 6 months 2. Pain on most days for the previous 3 months 3. Fulfil American College of Rheumatology (ACR) clinical criteria for OA of the knee: 3.1. Have an ACR functional class rating of II to IV 3.2. Failed to respond sufficiently 3.3. Intolerant to conservative treatment
Exclusion criteria
Exclusion criteria: Not provided at time of registration.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Western Ontario and McMaster Universities osteoarthritis index (WOMAC) pain sub-scores. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cost-utility based on health related quality of life measured by EuroQoL and self-reported healthcare utilisation for osteoarthritis | — |
Countries
Switzerland
Outcome results
None listed