Motor conversion (functional neurological) disorder Nervous System Diseases Motor conversion (functional neurological) disorder
Conditions
Interventions
Participants are initially provided with a detailed information sheet and have time to consider participation and to ask questions. Once a patient has provided written informed consent, they attend an
Sponsors
King's College London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. DSM5 diagnosis of motor conversion disorder made by consultant neurologist and/or neuropsychiatrist, causing weakness of at least one limb 2. Age =18 years 3. Ability to give written informed consent
Exclusion criteria
Exclusion criteria: 1. Epilepsy (or considered high risk of epilepsy from medical history) 2. Other contraindication to TMS (e.g. cochlear implants, metallic intracranial clips or intracranial surgery in last 12 months) 3. Comorbid organic neurological condition 4. Pain as primary symptom 5. Previous treatment with TMS (for any condition) 6. Non-fluent English speakers (if unable to accurately complete self-report questionnaires). 7. Major mental health disorder: current +/- previous diagnosis of schizophrenia or bipolar disorder; current drug/alcohol dependence 8. History of factitious disorder 9. Currently involved in another trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient reported changes in symptoms measured using the patient-rated Clinical Global Impression of Improvement scale (CGI-I) at TMS session 1, TMS session 2 and at follow-up. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Assessor-rated symptom change measured using clinician-rated Clinical Global Impression of Improvement scale (CGI-I) at TMS session 1, TMS session 2 and follow-up 2. Disability and activities of daily living measured using functional rating scales: SF-36, Barthel, FIM/FAM at TMS session 1, TMS session 2 and follow-up 3. Current symptom severity measured using objective and subjective measures of strength: dynamometry and patient ratings at TMS session 1, TMS session 2 and follow-up 4. Current psychological symptoms measured using self-report questionnaires: GAD7, PHQ9, PHQ15 and CORE-10 at TMS session 1, TMS session 2 and at follow-up 5. Psychosocial outcomes measured with a self-report questionnaire: Work and Social Adjustment Scale at TMS session 1, TMS session 2 and at follow-up 6. Health economics measured using the Client Service Receipt Inventory at TMS session 1, TMS session 2 and at follow-up | — |
Countries
United Kingdom
Contacts
Public ContactTim Nicholson
Outcome results
None listed