Calcium balance during haemodiafiltration and high flux haemodialysis

Study to investigate calcium balance during haemodiafiltration and high flux haemodialysis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN51182136

Enrollment

Registered

2013-11-01

Start date

2013-10-20

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal Urological and Genital Diseases

Interventions

1. ECG 2. Measurement of pre and post dialysis biochemistry including ionised serum calcium and dialysate biochemistries during haemodialysis and haemodiafiltration treatments

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Thrice weekly haemodialysis or haemodiafiltration 2. Ability to provide informed consent 3. Serum total calcium within laboratory normal reference range 4. Reliably functioning vascular access for dialysis

Exclusion criteria

Exclusion criteria: 1. Unable to provide informed consent 2. Aged 18 to 85 years 3. ECG with prolonged QTc 4. History of life-threatening cardiac arrhythmias 5. Recent myocardial infarction within previous 3 months 6. Admission to hospital for change in vascular access 7. Unlikely to survive 6 months 8. Planned living donor transplant 9. Patients with history of missing dialysis sessions

Design outcomes

Primary

Measure	Time frame
To determine whether there is a difference in calcium balance between haemodialysis and haemodiafiltration treatments. Calcium balance will be measured by comparing the amount of calcium delivered in the dialysate and that recovered in the spent dialysate, and the calcium flux (difference between the two) compared to measurements of calcium, and other electrolytes in blood tests at the start and end of calcium and parathyroid hormone concentrations.	—

Measure

Time frame

To determine whether there is a difference in calcium balance between haemodialysis and haemodiafiltration treatments. Calcium balance will be measured by comparing the amount of calcium delivered in the dialysate and that recovered in the spent dialysate, and the calcium flux (difference between the two) compared to measurements of calcium, and other electrolytes in blood tests at the start and end of calcium and parathyroid hormone concentrations.

—

Secondary

Measure	Time frame
Sodium and other electrolyte balance, changes in blood pressure and fluid removal and ECG changes	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026