Gut/intestinal permeability in healthy and physically active sports people Not Applicable
Conditions
Interventions
The 4 experimental arms are as follows:
1. Placebo (twice per day: 10 g milk protein concentrate [total = 20 g/d] and 1 gelatin capsule containing 37.5 mg of microcrystalline cellulose [total = 75 mg/
Sponsors
Aberystwyth University (UK)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Healthy adult (18 - 45 years), at least recreationally active and familiar with running exercise 2. Able to pass all pre-screening questions on standard Physical Activity Readiness questionnaire and hence lowest risk stratification (e.g. according to ACSM risk categories for physical exercise)
Exclusion criteria
Exclusion criteria: 1. Having a current infection (or had an infection in the 3 weeks prior to the study) 2. Exhibiting risk factors for cardiovascular (CV) conditions, metabolic or intestinal 3. Disorders 4. Smoking 5. Regular consumption of vitamin or sports supplements 6. Regular consumption of medication; regular alcohol intake over 2 units per day 7. Intolerance or allergy to milk (or dairy) products 8. Currently participating in another study (or within 3 weeks of completing one) having given blood in the 3 weeks prior to the study not habitually physically active 9. People who have other conditions known to alter intestinal permeability such as bowel surgery or caeliac disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut permeability by urinary excreiton of non-matabolisable sugars (lactulose and rhamnose) over a 5 hour period (in which all urine is collected) after the oral ingestion of these test sugars. | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximal oxygen consumption (VO2max); Core body temperature during exercise; Heart rate, subjective rating of perceived exertion, gas exchange (oxygen consumption and carbon dioxide output) during exercise; Full blood count, blood lactate, and blood glucose concentrations pre and post exercise trials (2 d and 14 d supplementation points in each arm). | — |
Countries
United Kingdom
Outcome results
None listed