Brain imaging responses to food images and food in insulin resistance - intervention

Brain imaging responses to food images and food in insulin resistance: a single centre randomised observational treatment based case-control study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN51099878

Enrollment

Registered

2010-12-14

Start date

2010-12-01

Completion date

Unknown

Last updated

2018-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Diabetes Research Network

Interventions

Both insulin sensitive and insulin resistant volunteers identified as meeting the inclusion criteria during the initial screening study (UKCRN 9515, DRN 546, ISRCTN18732138), will undergo a series of

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: All subjects (insulin sensitive and insulin resistant): 1. Men 2. Age 18 - 65 years (inclusive at time of recruitment) 3. Right-handed 4. English speaking 5. No active medical illness including diabetes mellitus 6. Body mass index (BMI) less than or equal to 30 kg/m2 Insulin sensitive subjects: 7. No family history of diabetes mellitus 8. Insulin sensitive (determined by homeostatic model assessment - insulin resistance [HOMA2-IR] less than 1.47) Insulin resistant subjects: 9. First degree relatives of patients with type 2 diabetes mellitus 10. Insulin resistance (determined by HOMA2-IR) greater than or equal to 1.47

Exclusion criteria

Exclusion criteria: 1. Women 2. Left handedness 3. Current or past history of significant substance abuse or eating disorders 4. Use of medication that may affect brain activity (e.g. antidepressants, anticonvulsants, antipsychotic drugs), drugs for obesity (orlistat or sibutramine) or drugs that lower glucose (e.g. metformin, sulphonylureas, thiazolidinediones, incretins or insulin) 5. Inability to understand spoken and/or written English 6. Claustrophobia (because of the small bore of the MR scanner) 7. BMI greater than 30 kg/m2 8. Cortraindication to MRI (pacemaker in situ, extensive dental work, history of penetrating eye trauma, precense of surgical metal clips etc.) 9. Presence of diabetes

Design outcomes

Primary

Measure	Time frame
Brain responses to food measured by using functional magnetic resonance imaging	—

Secondary

Measure	Time frame
Insulin sensitivity, measured at each functional magnetic resonance imaging scan visit	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026