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Multidimensional family therapy (MDFT) treatment of adolescents with substance use disorders, focusing on risk and protective factors in major youth life domains

The effectiveness of outpatient multidimensional family therapy (MDFT) compared with outpatient treatment as usual in adolescents with a cannabis use disorder and other problem behaviour: a multicentre, trans-national randomised controlled trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN51014277
Enrollment
480
Registered
2010-03-17
Start date
2007-08-01
Completion date
Unknown
Last updated
2018-09-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cannabis abuse and cannabis dependence Mental and Behavioural Disorders Mental and behavioural disorders due to use of cannabinoids

Interventions

MDFT: 4 - 6 months
sessions 2 - 3 times a week. Office-based and home-based sessions with: 1. The adolescent alone 2. The parent(s) alone 3. The family = adolescent + parent(s), and 4. Representatives of other social sy

Sponsors

Erasmus Medical Centre (Netherlands)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Age of the adolescent 13 through 18 years, either sex 2. Diagnosis of cannabis use disorder 3. At least 1 parent willing to take part in the treatment programme 4. Informed consent by both adolescent and parent(s)

Exclusion criteria

Exclusion criteria: 1. Disorder requiring hospitalisation or other residential treatment 2. Intelligence Quotient (IQ) of adolescent below 70

Design outcomes

Primary

MeasureTime frame
1. MDFT reduces cannabis consumption more strongly than TAU in the 90-day periods preceding follow-up assessments points (a lower number of consumption days: TLFB = TimeLine Follow Back), the difference growing bigger over time 2. Number of urine tests indicative of cannabis use is lower in MDFT than in TAU at follow-up assessments points 3. In MDFT, youth show fewer (symptoms of) diagnoses of cannabis use disorders (as measured with the Adolescent Diagnostic Interview-Light [ADI-Light]) than in TAU at 12 months follow-up (the validated ADI-Light measures symptoms of substance use disorders). Assessment points: baseline, 12 months follow up.

Secondary

MeasureTime frame
1. MDFT reduces alcohol consumption to a greater extent than TAU, on the same measures and the same assessment points as outlined for cannabis 2. MDFT is superior to TAU in diminishing delinquent behaviour (less recidivism), as measured with the validated Adolescent and Parent Interviews, the Self-Reported Delinquency survey (SRD; lower score), lower scores on the delinquency sub-scales of Youth-Self Report (YSR) and its parent version, the Child Behaviour Checklist (CBCL). Also police and justice registration databases. Assessment points: baseline, 6 months and 12 months follow up. 3. MDFT improves family functioning more than TAU (validated Adolescent and Parent Interviews using the Family Environment Scale [FES]). Interviews: baseline, 6 months and 12 months follow-up. FES: idem, but also 9-months follow up. 4. MDFT improves the youth's performance at school or work more than TAU (validated Adolescent and Parent Interviews, school reports, truancy logs). Assessment points: baseline, 6 months and 12 months follow up.

Countries

Belgium, France, Germany, Netherlands, Switzerland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 31, 2026