Hydration status Haematological Disorders Hydration status
Conditions
Interventions
Participants attend the laboratory for four experimental trial days which are conducted in a single blind randomised cross-over fashion at the same time of day and exactly one week apart.
control), 30mM [K+] (30K), 45mM [K+] (45K) and 60mM [K+] (60K) respectively. The composition of the drinks ingested is based on a standardized 3% carbohydrate (dextrose) solution containing 5mM sodium
Sponsors
University of Stirling
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Healthy male volunteers 2. Aged 18-35 3. No known cardiovascular, renal or metabolic disease/disorder 4. Moderate activity level
Exclusion criteria
Exclusion criteria: 1. Female participants 2. Participants currently taking diuretic and/or blood pressure medication 3. Previously/currently suffering from cardiovascular, renal or metabolic disease/disorder 4. Participants actively seeking to gain/lose weight
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Net Fluid Balance assessed at hourly intervals during the 2 hour observation period (fluid consumed minus cumulative urine output) in each study visit 2. Hydration Index assessed using total urine output on control divided by total urine output at the culmination of the 2 hour observation period in each study visit | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Sodium and Potassium net balances (intake minus urine losses) is assessed immediately post-consumption and at hourly intervals following drink consumption for 2 hours on each trial day using the flame photometry method within 5 days of urine sample collection 2. Body Mass measurements are taken using electronic scales for comparison between participants' 'hypohydrated' body mass (pre-drink consumption) and body mass at the culmination of the 2 hour observation period (2 hours post-drink consumption) on each trial day 3. Urine osmolality is assessed using the freezing point depression method within 48 hours of urine sample collection at baseline (pre-drink consumption) and at hourly intervals following drink consumption for 2 hours on each trial day | — |
Countries
United Kingdom
Outcome results
None listed