Topic: Generic Health Relevance and Cross Cutting Themes
Conditions
Interventions
Each child will only attend one group, either HRT or psychoeducation. Randomisation will be carried out by researchers (with coded data in at attempt to remain blind to treatment condition) using rele
Sponsors
Great Ormond Street Hospital For Children NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Participants will be recruited from the specialist TS Clinic at Great Ormond Street Hospital. All children seen at the clinic over the past five years will be invited retrospectively. New referrals to the clinic during recruitment will also be considered. Inclusion criteria will be: 1. Male or female children aged 9-14yrs 2. Diagnosis of Tourette Syndrome or Chronic Tic Disorder 3. Score on YGTSS (Yale Global Tic Severity Scale) > 13 4. Ideally live within one hour of London
Exclusion criteria
Exclusion criteria: 1. Learning Disability [Full Scale Intelligence Quotient (FSIQ) < 80, following Piacentini et al., 2010 and Woods et al., 2011] 2. Psychotic symptoms 3. Those who have had more than four sessions of HRT or Comprehensive Behavioral Intervention for Tics (CBIT) before (as in Piacentini et al., 2010 and Woods et al., 2011) 4. Those who have attended a psycho-educational group within the last two years 5. Children who do not speak English as a first language 6. Current substance abuse / dependence 7. Those who do not have internet access at home (a requirement for the tests used during home visits)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tic severity, which will be measured using the Yale Global Tic Severity Scale (Leckman et al., 1989), is a well validated semi-structured clinical interview carried out with parent and child. Questions relate to tic severity over the previous week. Separate ratings are recorded for motor and phonic tics in terms of number, frequency, intensity, complexity, and interference. These are combined to give an overall tic severity score. Measures to characterise the groups 1. Parent and child versions of the 32-item ChOCI-R self-report scale (Uher et al., 2008) as a measure OCD symtomatology. 2. A seven subtest short-form version of the Wechsler Intelligence Scales for Children (Crawford et al., 2010) as a measure of intellectual ability. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Tics will be directly observed for 15 minutes and five minutes of tic suppression. This will follow the protocol used by (Himle et al., 2006) 2. Premonitory Urge for Tics Scale (Woods et al., 2005) Gilles de la Tourette Syndrome?Quality of Life scale - Child versions(Cavanna et al., 2008) 3. Paediatric Quality of Life Inventory Version 4.0 (Varni, Seid, & Kurtin, 2001) 4. Strengths and Difficulties Questionnaire (Goodman, 1997) 5. A brief 4-item anger outbursts screen included at the beginning of the Rage Attacks Questionnaire (used in Budman et al., 2003) 6. Tourette Syndrome Questionnaire is a 5-item visual analogue scale which assesses participants' confidence with and acceptance of their tics. The scale was developed by Dr Murphy and is used clinically within group work for children with TS at GOSH 7. The Dimensional Change Card Sort Test Executive Function (NIH Toolbox) is a measure of cognitive flexibility 8. The Flanker Inhibitory Control and Attention Test ? Executive Function (NIH Toolbox) 9. The Motor Dexterity Test (NIH Toolbox) is a simple measure of fine motor skills 10. SNAP-IV - a 26-item parent-report scale (Swanson et al., 2001) as a measure of ADHD symptomatology | — |
Countries
United Kingdom
Outcome results
None listed