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What works for whom? Comparing Narrative Exposure Therapy and extended Problem Management Plus for trauma survivors in post-war Northern Uganda

One size fits all? Towards individual prediction of treatment success for posttraumatic stress disorder in post-conflict settings

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN50726317
Enrollment
660
Registered
2025-11-06
Start date
2025-11-23
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Posttraumatic Stress Disorder (PTSD) Mental and Behavioural Disorders

Interventions

Eligible participants will be randomized using block randomization stratified by mental health worker, ensuring that each mental health worker treats an approximately equal number of participants in e

Sponsors

Klinische Psychologie und Psychotherapie
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged between 18 and 65 years 2. Survivor of trauma related to the LRA conflict or ongoing violence in the post-conflict setting 3. Probable diagnosis of PTSD according to DSM-5 (PSSI-5)

Exclusion criteria

Exclusion criteria: 1. Clinical signs of acute psychosis 2. Clinical signs of mental retardation that would interfere with psychosocial interventions 3. High alcohol abuse (AUDIT score >= 8) constitutes an exclusion criterion if the client is not willing and confident to be able to reduce the consumption during treatment 4. Drug abuse 5. Concurrent psychotherapy 6. Medication with benzodiazepines, as this medication might interfere with exposure-based psychotherapy (Singewald et al., 2015) 7. Acute risk of suicidality/ endangerment of others that would require immediate hospitalization of the client

Design outcomes

Primary

MeasureTime frame
PTSD symptom severity measured using the Posttraumatic Stress Disorder Symptom Scale Interview for DSM-5 (PSSI-5) sum score at baseline and 3 and 12 months after randomization

Secondary

MeasureTime frame
1. Depressive symptom severity measured using the sum score of the 9-item version of the patient health questionnaire (PHQ-9) at baseline and 3 and 12 months after randomization 2. Anxiety symptom severity measured using the GAD-7 sum score at baseline and 3 and 12 months after randomization

Countries

Uganda

Contacts

Public ContactSarah Wilker
sarah.wilker@uni-bielefeld.de+49 (0)5211064491

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026