Comparison of outcomes of goal-directed fluid optimisation guided by LiDCOrapid and conventional oesophageal Doppler

Comparison of goal-directed fluid optimisation guided by LiDCOrapid and conventional oesophageal Doppler ? effect on intra-operative oxygen delivery index and post-operative outcomes: a randomised control non-inferiority study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN50251697

Enrollment

336

Registered

2012-09-14

Start date

2011-05-24

Completion date

Unknown

Last updated

2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Improving perioperative care for elective colorectal surgery Surgery

Interventions

Anaesthetist randomised to use either: 1. LiDCOrapid in intervention group OR 2. Conventional oesophageal Doppler cardiac output monitoring in control arm to guide goal-directed fluid therapy Both m

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Elective or semi-elective patients due to undergo colorectal surgery as part of Enhanced Recovery Protocol 2. Successful simultaneous LiDCOrapid and oesophageal Doppler monitoring throughout surgery

Exclusion criteria

Exclusion criteria: 1. Emergency surgery 2. Lack of capacity to consent 3. Pregnancy 4. All excluded patients from patient groups to be reported in results 5. Contraindications to oesophageal Doppler probe 5.1. nasal injuries or polyps 5.2. severe oesophageal/laryngeal/pharyngeal disease 5.3. recent oesophageal/laryngeal/pharyngeal surgery 5.4. thoracic aortic aneurysm 5.5. severe bleeding diathesis 5.6. long-term systemic steroid therapy 5.7. portal hypertension 6. Contraindications to arterial line or LiDCOrapid 6.1. weight <40kg 6.2. aortic valve regurgitation

Design outcomes

Primary

Measure	Time frame
Post-operative length of stay (in days)	—

Secondary

Measure	Time frame
1. Intra-operative oxygen delivery index values 2. Intra-operative intravenous fluid volumes 3. Intra-operative differences in % change stroke volume 4. Morbidity 5. Functional recovery (mobility and return of gastrointestinal function) 6. In-hospital and 30-day mortality	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026